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KMID : 0356620120270030173
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Journal of Korean Society of Endocrinology
2012 Volume.27 No. 3 p.173 ~ p.252
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RET: A Multi-Faceted Gene in Human Cancer
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Massimo Santoro
Francesca Carlomagno
Rosa Marina Melillo
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Abstract
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REarranged during Transfection (RET) gene encodes a receptor tyrosine kinase and it was initially discovered as an in vitro transforming gene. For many years, RET has been involved in papillary thyroid carcinoma and medullary thyroid carcinoma. More recently, lung adenocarcinoma and chronic myelomonocytic leukemia samples have been found to display RET gene rearrangements. This knowledge is stimulating the search for protein kinase inhibitors to combat RET-driven malignancies.
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KEYWORD
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Kinase, Neoplasms, Oncogenes, Rearranged during transfection, Signal transduction, Thyroid
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